Comparative genomics of 10 new Caenorhabditis species

L Stevens, MA Félix, T Beltran, C Braendle… - Evolution …, 2019 - academic.oup.com
The nematode Caenorhabditis elegans has been central to the understanding of metazoan
biology. However, C. elegans is but one species among millions and the significance of this …

[HTML][HTML] Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity

…, CE Requena, A Gomes, M Emperle, T Beltran… - Nature …, 2018 - nature.com
Methylation at the 5 position of cytosine in DNA (5meC) is a key epigenetic mark in eukaryotes.
Once introduced, 5meC can be maintained through DNA replication by the activity of ‘…

Epimutations driven by small RNAs arise frequently but most have limited duration in Caenorhabditis elegans

T Beltran, V Shahrezaei, V Katju… - Nature Ecology & Evolution, 2020 - nature.com
Epigenetic regulation involves changes in gene expression independent of DNA sequence
variation that are inherited through cell division. In addition to a fundamental role in cell …

Integrator is recruited to promoter‐proximally paused RNA Pol II to generate Caenorhabditis elegans piRNA precursors

T Beltran, E Pahita, S Ghosh, B Lenhard… - The EMBO journal, 2021 - embopress.org
Piwi‐interacting RNAs (piRNAs) play key roles in germline development and genome defence
in metazoans. In C. elegans, piRNAs are transcribed from > 15,000 discrete genomic loci …

[PDF][PDF] Comparative epigenomics reveals that RNA polymerase II pausing and chromatin domain organization control nematode piRNA biogenesis

T Beltran, C Barroso, TY Birkle, L Stevens… - Developmental Cell, 2019 - cell.com
Piwi-interacting RNAs (piRNAs) are important for genome regulation across metazoans, but
their biogenesis evolves rapidly. In Caenorhabditis elegans, piRNA loci are clustered within …

The RNA polymerase II subunit RPB‐9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription

…, G Furlan, L Lampersberger, T Beltran… - The EMBO …, 2021 - embopress.org
PIWI‐interacting RNAs (piRNAs) are genome‐encoded small RNAs that regulate germ cell
development and maintain germline integrity in many animals. Mature piRNAs engage Piwi …

[HTML][HTML] Long-term experimental evolution reveals purifying selection on piRNA-mediated control of transposable element expression

…, CJ Sheeba, A Konrad, T Belicard, T Beltran… - BMC biology, 2020 - Springer
Background Transposable elements (TEs) are an almost universal constituent of eukaryotic
genomes. In animals, Piwi-interacting small RNAs (piRNAs) and repressive chromatin often …

Deep indel mutagenesis reveals the impact of insertions and deletions on protein stability and function

M Topolska, T Beltran, B Lehner - bioRxiv, 2023 - biorxiv.org
Amino acid insertions and deletions (indels) are an abundant class of genetic variants.
However, compared to substitutions, the effects of indels are not well understood and poorly …

Epimutations driven by small RNAs arise frequently but have limited duration in a metazoan organism

T Beltran, V Shahrezaei, V Katju, P Sarkies - BiorXiv, 2019 - biorxiv.org
Epigenetic regulation involves changes in gene expression independent of DNA sequence
variation that are inherited through cell division ( Holliday, 2006 ). In addition to a …

Evolutionary analysis implicates RNA polymerase II pausing and chromatin structure in nematode piRNA biogenesis

T Beltran, C Barroso, TY Birkle, L Stevens, HT Schwartz… - BioRxiv, 2018 - biorxiv.org
Piwi-interacting RNAs (piRNAs) control transposable elements widely across metazoans but
have rapidly evolving biogenesis pathways. In Caenorhabditis elegans, almost all piRNA …