User profiles for Toni Delorey
 | Toni DeloreyBroad institute Verified email at broadinstitute.org Cited by 4603 |
[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
A single-cell survey of the small intestinal epithelium
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and
help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial …
help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial …
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer.
Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform …
Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform …
[HTML][HTML] Spatially organized multicellular immune hubs in human colorectal cancer
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To …
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To …
[HTML][HTML] A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries
…, A Barry, J Abreu, B Minie, J Nolan, TM Delorey… - Genome biology, 2011 - Springer
Genome targeting methods enable cost-effective capture of specific subsets of the genome
for sequencing. We present here an automated, highly scalable method for carrying out the …
for sequencing. We present here an automated, highly scalable method for carrying out the …
Dynamic profiling of the protein life cycle in response to pathogens
INTRODUCTION Mammalian gene expression is tightly controlled through the interplay
between the RNA and protein life cycles. Although studies of individual genes have shown that …
between the RNA and protein life cycles. Although studies of individual genes have shown that …
[PDF][PDF] Emergence of a high-plasticity cell state during lung cancer evolution
Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung …
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung …
[HTML][HTML] Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
…, A Bollhagen, PI Thakore, D Dionne, TM Delorey… - Cell, 2021 - cell.com
While intestinal Th17 cells are critical for maintaining tissue homeostasis, recent studies
have implicated their roles in the development of extra-intestinal autoimmune diseases …
have implicated their roles in the development of extra-intestinal autoimmune diseases …
B-cell-specific checkpoint molecules that regulate anti-tumour immunity
…, RM Barilla, S Zaghouani, E Christian, TM Delorey… - Nature, 2023 - nature.com
The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies
have focused on targeting T and natural killer cells to inhibit tumour growth 1 , 2 . Here, …
have focused on targeting T and natural killer cells to inhibit tumour growth 1 , 2 . Here, …
The evolution of drug resistance in clinical isolates of Candida albicans
10.7554/eLife.00662.001 Candida albicans is both a member of the healthy human
microbiome and a major pathogen in immunocompromised individuals. Infections are typically …
microbiome and a major pathogen in immunocompromised individuals. Infections are typically …