User profiles for Toni Seppälä
 | Toni T. SeppäläUniversity of Tampere Verified email at tuni.fi Cited by 5183 |
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database
P Møller, TT Seppälä, I Bernstein, E Holinski-Feder… - Gut, 2018 - gut.bmj.com
Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive
both their first and subsequent cancers, resulting in a growing number of older patients with …
both their first and subsequent cancers, resulting in a growing number of older patients with …
[HTML][HTML] Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome
and result in different but imprecisely known cancer risks. This study aimed to provide …
and result in different but imprecisely known cancer risks. This study aimed to provide …
Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome …
P Møller, T Seppälä, I Bernstein, E Holinski-Feder… - Gut, 2017 - gut.bmj.com
Objective Estimates of cancer risk and the effects of surveillance in Lynch syndrome have
been subject to bias, partly through reliance on retrospective studies. We sought to establish …
been subject to bias, partly through reliance on retrospective studies. We sought to establish …
[HTML][HTML] Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a …
Background Lynch syndrome is associated with an increased risk of colorectal cancer and
with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group …
with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group …
[HTML][HTML] Genetic and epigenetic characteristics of inflammatory bowel Disease–Associated colorectal cancer
…, N Välimäki, A Kuosmanen, RM Plaketti, TT Seppälä… - Gastroenterology, 2021 - Elsevier
Background & Aims Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory
disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC (…
disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC (…
[HTML][HTML] The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
…, M Bonsack, S Schott, H Bläker, T Seppälä… - Nature …, 2020 - nature.com
The immune system can recognize and attack cancer cells, especially those with a high load
of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair …
of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair …
Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome …
P Møller, T Seppälä, I Bernstein, E Holinski-Feder… - Gut, 2017 - gut.bmj.com
Objective Today most patients with Lynch syndrome (LS) survive their first cancer. There is
limited information on the incidences and outcome of subsequent cancers. The present study …
limited information on the incidences and outcome of subsequent cancers. The present study …
No difference in colorectal cancer incidence or stage at detection by colonoscopy among 3 countries with different Lynch syndrome surveillance policies
Background & Aims Patients with Lynch syndrome are at high risk for developing colorectal
cancer (CRC). Regular colonoscopic surveillance is recommended, but there is no …
cancer (CRC). Regular colonoscopic surveillance is recommended, but there is no …
[HTML][HTML] Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus
…, M Lumela, J Rummukainen, O Nerg, TT Seppälä… - PloS one, 2014 - journals.plos.org
Background The significance of amyloid precursor protein (APP) and neuroinflammation in
idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown. …
idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown. …
[HTML][HTML] Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
Background The CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint interaction may promote
cancer progression, but the expression patterns and prognostic significance of PD-L1 and …
cancer progression, but the expression patterns and prognostic significance of PD-L1 and …