Communication between cells assumes particular importance in multicellular organisms.
The growth, migration and differentiation of cells in the embryo, and their organization into …

The discovery that Src homology 2 (SH2) domains provide phosphorylation-dependent and
sequence-specific contacts for assembly of receptor signaling complexes has provided a …

Src homology (SH) regions 2 and 3 are noncatalytic domains that are conserved among a
series of cytoplasmic signaling proteins regulated by receptor protein-tyrosine kinases, …

The sequencing of complete genomes provides a list that includes the proteins responsible
for cellular regulation. However, this does not immediately reveal what these proteins do, nor …

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …

Affinity purification coupled with mass spectrometry (AP-MS) is a widely used approach for
the identification of protein-protein interactions. However, for any given protein of interest, …

Cells chemically isolate molecules in compartments to both facilitate and regulate their
interactions. In addition to membrane-encapsulated compartments, cells can form proteinaceous …

Over the last two decades, a new and unifying concept of cellular organization has emerged
in which modular protein-protein interactions provide an underlying framework through …

Abstract Changes in the biochemical wiring of oncogenic cells drives phenotypic transformations
that directly affect disease outcome. Here we examine the dynamic structure of the …

The recent abundance of genome sequence data has brought an urgent need for systematic
proteomics to decipher the encoded protein networks that dictate cellular function 1 . To …