As human lifespan increases, a greater fraction of the population is suffering from age-related
cognitive impairments, making it important to elucidate a means to combat the effects of …

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Aging is a predominant risk factor for several chronic diseases that limit healthspan 1 .
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets. Blood …

Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

Microglia become progressively activated and seemingly dysfunctional with age, and
genetic studies have linked these cells to the pathogenesis of a growing number of …

Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer’s disease (AD)
brain, and it does so with the full complexity of local peripheral inflammatory responses. …

Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by
excessive deposition of amyloid-β (Aβ) peptides in the brain. One of the earliest …

In the central nervous system, ageing results in a precipitous decline in adult neural stem/progenitor
cells and neurogenesis, with concomitant impairments in cognitive functions 1 . …

The human brain vasculature is of great medical importance: its dysfunction causes disability
and death 1 , and the specialized structure it forms—the blood–brain barrier—impedes the …

A molecular test for Alzheimer's disease could lead to better treatment and therapies. We
found 18 signaling proteins in blood plasma that can be used to classify blinded samples from …