User profiles for Torbjörn Gräslund
 | Torbjörn GräslundProfessor at KTH Royal Institute of Technology, Stockholm, Sweden Verified email at kth.se Cited by 2263 |
Affibody molecules in biotechnological and medical applications
Affibody molecules are small (6.5-kDa) affinity proteins based on a three-helix bundle
domain framework. Since their introduction 20 years ago as an alternative to antibodies for …
domain framework. Since their introduction 20 years ago as an alternative to antibodies for …
Improving the tolerance of a protein a analogue to repeated alkaline exposures using a bypass mutagenesis approach
M Linhult, S Gülich, T Gräslund, A Simon… - Proteins: structure …, 2004 - Wiley Online Library
Staphylococcal protein A (SPA) is a cell surface protein expressed by Staphylococcus aureus.
It consists of five repetitive domains. The five SPA‐domains show individual interaction to …
It consists of five repetitive domains. The five SPA‐domains show individual interaction to …
[HTML][HTML] S100A4 interacts with p53 in the nucleus and promotes p53 degradation
S100A4 is a small calcium-binding protein that is commonly overexpressed in a range of
different tumor types, and it is widely accepted that S100A4 has an important role in the process …
different tumor types, and it is widely accepted that S100A4 has an important role in the process …
HEHEHE-Tagged Affibody Molecule May Be Purified by IMAC, Is Conveniently Labeled with [99mTc(CO)3]+, and Shows Improved Biodistribution with Reduced …
…, L Abrahmsén, A Orlova, T Gräslund - Bioconjugate …, 2010 - ACS Publications
Affibody molecules are a class of small (ca. 7 kDa) robust scaffold proteins suitable for
radionuclide molecular imaging of therapeutic targets in vivo. A hexahistidine tag at the N-…
radionuclide molecular imaging of therapeutic targets in vivo. A hexahistidine tag at the N-…
[HTML][HTML] Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of γ-globin expression …
T Gräslund, X Li, L Magnenat, M Popkov… - Journal of Biological …, 2005 - ASBMB
Artificial transcription factors can be engineered to interact with specific DNA sequences to
modulate endogenous gene expression within cells. A significant hurdle to implementation of …
modulate endogenous gene expression within cells. A significant hurdle to implementation of …
Affibody-derived drug conjugates: Potent cytotoxic molecules for treatment of HER2 over-expressing tumors
Patients with HER2-positive tumors often suffer resistance to therapy, warranting development
of novel treatment modalities. Affibody molecules are small affinity proteins which can be …
of novel treatment modalities. Affibody molecules are small affinity proteins which can be …
Use of a HEHEHE purification tag instead of a hexahistidine tag improves biodistribution of affibody molecules site-specifically labeled with 99mTc, 111In, and 125I
…, M Altai, F Wångsell, T Gräslund… - Journal of medicinal …, 2011 - ACS Publications
Affibody molecules are a class of small (∼7 kDa) robust scaffold proteins suitable for
radionuclide molecular imaging in vivo. The attachment of a hexahistidine (His 6 )-tag to the …
radionuclide molecular imaging in vivo. The attachment of a hexahistidine (His 6 )-tag to the …
HAHAHA, HEHEHE, HIHIHI, or HKHKHK: Influence of Position and Composition of Histidine Containing Tags on Biodistribution of [99mTc(CO)3]+-Labeled Affibody …
Engineered affibody molecules can be used for high contrast in vivo molecular imaging.
Extending a recombinantly produced HER2 binding affibody molecule with a hexa-histidine tag …
Extending a recombinantly produced HER2 binding affibody molecule with a hexa-histidine tag …
An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein
Proteins endocytosed from serum are degraded in the lysosomes. However, serum albumin
(SA) and IgG, through its Fc part, bind to the neonatal Fc receptor (FcRn) at low pH in the …
(SA) and IgG, through its Fc part, bind to the neonatal Fc receptor (FcRn) at low pH in the …
Evolution of programmable zinc finger-recombinases with activity in human cells
RM Gordley, JD Smith, T Gräslund… - Journal of molecular …, 2007 - Elsevier
Site-specific recombinases are important tools for genomic engineering in many living systems.
Applications of recombinases are, however, constrained by the DNA targeting endemic …
Applications of recombinases are, however, constrained by the DNA targeting endemic …