Muscle cells are a syncytium in which the many nuclei are positioned to maximize the distance
between adjacent nuclei. Although mispositioned nuclei are correlated with many muscle …

Nuclear movement is a fundamental process of eukaryotic cell biology. Skeletal muscle
presents an intriguing model to study nuclear movement because its development requires the …

Background A strength of Drosophila as a model system is its utility as a tool to screen for
novel regulators of various functional and developmental processes. However, the utility of …

Using Drosophila muscle development as a model system makes possible the identification
of genetic pathways, temporal regulation of development, mechanisms of cellular …

Mispositioned nuclei are a hallmark of skeletal muscle disease. Many of the genes that are
linked to Emery–Dreifuss muscular dystrophy (EDMD) encode proteins that are critical for …

The even positioning of nuclei at the periphery of differentiated myofibers is among the most
striking examples of cellular organization. In this issue of Developmental Cell, Roman et al. (…

Nuclear movement is a fundamental process of eukaryotic cell biology. Skeletal muscle
presents an intriguing model to study nuclear movement because its development requires the …

Cardiovascular disease (CVD) is the leading cause of death worldwide. CVD is associated
with insomnia such that insomnia symptoms double the risk of incident CVD. However, how …

… To my parents, Tina and Paul Mandigo, thank you for allowing your son to move to the big
city … To my wife, Chelsea Mandigo, your support throughout graduate school has meant more …

Background: Insomnia symptoms have been associated with CVD, doubling the risk of
incident CVD, but specific shared pathways remain poorly understood. Recently, genome-wide …