[PDF][PDF] 3D RNA and functional interactions from evolutionary couplings
Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far outpaces
the research on the structure and functional interactions of these RNA gene sequences. …
the research on the structure and functional interactions of these RNA gene sequences. …
Modelling signalling networks from perturbation data
Motivation Intracellular signalling is realized by complex signalling networks, which are almost
impossible to understand without network models, especially if feedbacks are involved. …
impossible to understand without network models, especially if feedbacks are involved. …
[HTML][HTML] In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis
…, N Narayan, C Del Valle, T Gross… - Nature Genetics, 2023 - nature.com
Cellular differentiation requires extensive alterations in chromatin structure and function,
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …
Identifiability and experimental design in perturbation studies
T Gross, N Blüthgen - Bioinformatics, 2020 - academic.oup.com
Motivation A common strategy to infer and quantify interactions between components of a
biological system is to deduce them from the network’s response to targeted perturbations. …
biological system is to deduce them from the network’s response to targeted perturbations. …
[PDF][PDF] RECOVER identifies synergistic drug combinations in vitro through sequential model optimization
For large libraries of small molecules, exhaustive combinatorial chemical screens become
infeasible to perform when considering a range of disease models, assay conditions, and …
infeasible to perform when considering a range of disease models, assay conditions, and …
scPerturb: harmonized single-cell perturbation data
Abstract Analysis across a growing number of single-cell perturbation datasets is hampered
by poor data interoperability. To facilitate development and benchmarking of computational …
by poor data interoperability. To facilitate development and benchmarking of computational …
Recover: sequential model optimization platform for combination drug repurposing identifies novel synergistic compounds in vitro
For large libraries of small molecules, exhaustive combinatorial chemical screens become
infeasible to perform when considering a range of disease models, assay conditions, and …
infeasible to perform when considering a range of disease models, assay conditions, and …
Optical fibre switches based on full wafer silicon micromachining
M Hoffmann, P Kopka, T Gross… - … of Micromechanics and …, 1999 - iopscience.iop.org
An optical (1× 2) moving-fibre switch with bistable operation is presented. The low cost
fabrication process based on bulk anisotropic Si etching for thermal actuators with cross sections …
fabrication process based on bulk anisotropic Si etching for thermal actuators with cross sections …
High-precision cryogenic wheel mechanisms for the JWST NIRSpec instrument
…, M Fischer, MM Ellenrieder, T Gross… - … in Telescopes and …, 2008 - spiedigitallibrary.org
The Grating and Filter Wheel Mechanisms of the JWST NIRSpec instrument allow for
reconfiguration of the spectrograph in space in a number of NIR sub-bands and spectral resolutions…
reconfiguration of the spectrograph in space in a number of NIR sub-bands and spectral resolutions…
[PDF][PDF] scPerturb: Information resource for harmonized single-cell perturbation data
Recent biotechnological advances led to growing numbers of single-cell studies, which
reveal molecular and phenotypic responses to large numbers of perturbations. However, …
reveal molecular and phenotypic responses to large numbers of perturbations. However, …