To elucidate the evolution of germ cell specification in Metazoa, recent comparative studies
focus on ancestral animal groups. Here, we followed the germline throughout the life cycle of …

Addressing the complexity of organogenesis at a system-wide level requires a complete
understanding of adult cell types, their origin, and precursor relationships. The Drosophila ovary …

Organ function relies on the spatial organization and functional coordination of numerous
cell types. The Drosophila ovary is a widely used model system to study the cellular activities …

Single-cell migration is a key process in development, homeostasis, and disease. Nevertheless,
the control over basic cellular mechanisms directing cells into motile behavior in vivo is …

10.7554/eLife.05279.001 Cell migration and polarization is controlled by signals in the
environment. Migrating cells typically form filopodia that extend from the cell surface, but the …

Fertility and gamete reserves are maintained by asymmetric divisions of the germline stem
cells to produce new stem cells or daughters that differentiate as gametes. Before entering …

Two different compartments support germline stem cell (GSC) self-renewal and their timely
differentiation: the classical niche provides maintenance cues, while a differentiation …

The Hu proteins are RNA‐binding proteins known to be involved in various aspects of RNA
metabolism, such as nucleo‐cytoplasmic shuttling, translation, and stability. These proteins …

The identification of small RNA molecules and the elucidation of their functions in the cell
enhanced our understanding of the mechanisms controlling gene expression at the …

Organogenesis requires exquisite spatiotemporal coordination of cell morphogenesis, migration,
proliferation, and differentiation of multiple cell types. For gonads, this involves complex …