User profiles for Toru Takumi
 | Toru TakumiVerified email at med.kobe-u.ac.jp Cited by 14302 |
Cloning of a membrane protein that induces a slow voltage-gated potassium current
T Takumi, H Ohkubo, S Nakanishi - Science, 1988 - science.org
A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium
current on its expression in Xenopus oocytes was identified by combining molecular cloning …
current on its expression in Xenopus oocytes was identified by combining molecular cloning …
Mutations of optineurin in amyotrophic lateral sclerosis
…, T Hirai, T Kato, K Ogasawara, A Hirano, T Takumi… - Nature, 2010 - nature.com
Amyotrophic lateral sclerosis (ALS) has its onset in middle age and is a progressive disorder
characterized by degeneration of motor neurons of the primary motor cortex, brainstem and …
characterized by degeneration of motor neurons of the primary motor cortex, brainstem and …
Postsynaptic density proteins and their involvement in neurodevelopmental disorders
Synaptic connections are essential for neural circuits in order to convey brain functions. The
postsynaptic density (PSD) is a huge protein complex associated with postsynaptic …
postsynaptic density (PSD) is a huge protein complex associated with postsynaptic …
[HTML][HTML] Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism
Substantial evidence suggests that chromosomal abnormalities contribute to the risk of
autism. The duplication of human chromosome 15q11-13 is known to be the most frequent …
autism. The duplication of human chromosome 15q11-13 is known to be the most frequent …
[HTML][HTML] Transcriptional oscillation of canonical clock genes in mouse peripheral tissues
…, H Soma, M Akashi, T Mamine, T Takumi - BMC molecular …, 2004 - Springer
Background The circadian rhythm of about 24 hours is a fundamental physiological function
observed in almost all organisms from prokaryotes to humans. Identification of clock genes …
observed in almost all organisms from prokaryotes to humans. Identification of clock genes …
Behavioral neuroscience of autism
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Several genetic causes
of ASD have been identified and this has enabled researchers to construct mouse models. …
of ASD have been identified and this has enabled researchers to construct mouse models. …
[HTML][HTML] CNV biology in neurodevelopmental disorders
T Takumi, K Tamada - Current Opinion in Neurobiology, 2018 - Elsevier
Highlights • Pathogenic CNVs are shared among neurodevelopmental and neuropsychiatric
disorders. • Understanding epigenetic regulation provides important insights not only into …
disorders. • Understanding epigenetic regulation provides important insights not only into …
Genomic and genetic aspects of autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic
component. The past decade has witnessed tremendous progress in the genetic studies of ASD…
component. The past decade has witnessed tremendous progress in the genetic studies of ASD…
The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1
M Akashi, T Takumi - Nature structural & molecular biology, 2005 - nature.com
The PAS (PER-ARNT-SIM) helix-loop-helix transcription factor BMAL1 (also known as MOP3)
is an essential component of the circadian pacemaker in mammals. Here we show that the …
is an essential component of the circadian pacemaker in mammals. Here we show that the …
[HTML][HTML] The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology
…, T Tachibana, T Nishikawa, GG Hicks, T Takumi - Current biology, 2005 - cell.com
Neuronal dendrites, together with dendritic spines, exhibit enormously diverse structure [1].
Selective targeting and local translation of mRNAs in dendritic spines have been implicated …
Selective targeting and local translation of mRNAs in dendritic spines have been implicated …