Psilocin (3-[2-(dimethylamino) ethyl]-1H-indol-4-ol) is a hallucinogenic component of the
Mexican mushroom Psilocybe mexicana and a skeletal serotonin (5-HT) analogue. Psilocin is …

Parkinson’s disease involves the progressive degeneration of dopaminergic neurons in the
substantia nigra. However, the etiology of the disease remains to be elucidated. …

We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular
level. In a mouse model under subacute cellular stress in which deficits in rule shifting tasks …

A synthesis of 1, 1-disubstituted 1, 2, 3, 4-tetrahydroisoquinolines (6) was achieved in a highly
efficient manner via Pictet–Spengler reaction of arylethylamines (1) and acyclic and cyclic …

Parkinsonism‐inducing neurotoxicity of 1,2,3,4‐tetrahydroisoquinoline (TIQ), as contrasted
to 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), and parkinsonism‐preventing …

The Pictet–Spengler cyclization of the imines (3) prepared by the condensation of L-tryptophan
methyl ester (1) and aryl methyl ketones (2), using titanium (IV) isopropoxide as an …

… Jun TODA, Shinobu MATSUMOTO, Toshiaki SAITOl—l, and Takehiro SANo* …

A synthesis of 6, 7-dimethoxy-3-phenyl-1, 2, 3, 4-tetrahydroisoquinoline (14a) and 7, 8-dimethoxy-2-phenyl-1,
2, 4, 5-tetrahydro-3H-3-benzazepine (14b) was achieved via the …

Improved synthesis of four stereoisomeric chiral 1, 3-dimethyl-1, 2, 3, 4-tetrahydroisoquinolines
(1a, b, ent-1a, b) was achieved via the super acid-induced cyclization of chiral N-[1-…

The simple alkyl sulfoxide 6 carrying two aromatic nucleophiles, when treated with
trifluoroacetic anhydride at room temperature (Pummerer reaction conditions), underwent an …