More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …

Recently, tetherin has been identified as an effective cellular factor that prevents the release
of human immunodeficiency virus type 1. Here, we show that the production of virus-like …

Nuclear reprogramming of somatic tissue enables derivation of induced pluripotent stem (iPS)
cells from an autologous, non-embryonic origin. The purpose of this study was to establish …

Nuclear reprogramming of adult somatic tissue enables embryo-independent generation of
autologous, patient-specific induced pluripotent stem (iPS) cells. Exploiting this emergent …

Nuclear reprogramming enables patient-specific derivation of induced pluripotent stem (iPS)
cells from adult tissue. Yet, iPS generation from patients with type 2 diabetes (T2D) has not …

Streptozotocin (STZ), a glucosamine-nitrosourea compound, has potent genotoxic effects
on pancreatic β-cells and is frequently used to induce diabetes in experimental animals. …

Protection of β cells from autoimmune destruction potentially cures type 1 diabetes mellitus (T1D).
During antigen presentation, interactions between cytotoxic T-lymphocyte antigen-4 (…

Introduction End-stage renal disease (ESRD) is a major public health problem. Although
kidney transplantation is a viable therapeutic option, this therapy is associated with significant …

BACKGROUND B-type natriuretic peptide (BNP), a key cardiac hormone in cardiorenal
homeostasis, is produced as a 108 amino acid prohormone, proBNP1-108, which is converted to …

Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host
cell machinery during co-infection by adenoviruses and other helper viruses. In the absence …