Importance Previous evidence has implicated corticostriatal abnormalities in the pathophysiology
of psychosis. Although the striatum is the primary target of all efficacious antipsychotics…

Background In light of the evidence for brain white matter (WM) abnormalities in schizophrenia,
study of normal WM maturation in adolescence may provide critical insights relevant to …

Background: The clinical benefit of memantine for Alzheimer’s disease (AD) remains
inconclusive. Objective: We performed an updated systematic review and meta-analysis of the …

A systematic review and random-effects model network meta-analysis were conducted to
compare the efficacy, acceptability, tolerability, and safety of antidepressants to treat adults with …

Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) is associated
with the pathophysiology of major depressive disorder (MDD). In this mini review, we …

Background: Schizophrenia and bipolar disorder share aspects of phenomenology and
neurobiology and thus may represent a continuum of disease. Few studies have compared …

We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate
which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder …

A systematic review and random-effects model network meta-analysis was conducted to
compare the efficacy, acceptability, tolerability, and safety of pharmacological interventions for …

Recent data suggests that a history of childhood maltreatment is associated with reductions
in hippocampal volume in healthy adults. Because this association is also evident in adults …

Background Age-related differences in white matter tract microstructure have been well
established across the life span. In the present cross-sectional study, we examined whether …