Background: Insulin resistance is more common in overweight individuals and is associated
with increased risk for type 2 diabetes mellitus and cardiovascular disease. Given the …

Chronic inflammation characterized by T cell and macrophage infiltration of visceral adipose
tissue (VAT) is a hallmark of obesity-associated insulin resistance and glucose intolerance. …

ContextIncreased levels of asymmetric dimethylarginine (ADMA) are associated with endothelial
dysfunction and increased risk of cardiovascular disease. Several cardiovascular risk …

Objectives : The study goals were to: 1) define the relationship between body mass index (BMI)
and insulin resistance in 314 nondiabetic, normotensive, healthy volunteers; and 2) …

The goal of this study was to evaluate the ability of various routine measures of lipoprotein
metabolism to identify patients who were insulin resistant and dyslipidemic, and therefore, at …

Background— Plasma C-reactive protein (CRP) concentrations are increased in obese and/or
hyperinsulinemic individuals. The goal of this study was to determine if the relation …

Background: Studies on the relationship between regional fat and insulin resistance yield
mixed results. Our objective was to determine whether regional fat distribution, independent of …

The ability of insulin to stimulate glucose disposal varies more than six-fold in apparently
healthy individuals. The one third of the population that is most insulin resistant is at greatly …

Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its
early disease stages, its effects on biological processes or the transition to clinical T2D. To …

Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy, hypoxia,
and/or intestinal leakage of bacteria and their metabolic products, likely plays a critical role …