Approaches for computing small molecule binding free energies based on molecular
simulations are now regularly being employed by academic and industry practitioners to study …

Background Successful implementation of modified cyanobacteria as hosts for industrial
applications requires the development of a cyanobacterial chassis. The cyanobacterium …

Background Vaccine development for influenza A/H5N1 is an important public health priority,
but H5N1 vaccines are less immunogenic than seasonal influenza vaccines. Adjuvant …

The U2AF1 gene is a core part of mRNA splicing machinery and frequently contains somatic
mutations that contribute to oncogenesis in myelodysplastic syndrome, acute myeloid …

Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly
strain-specific and limited heterosubtypic responses. To better understand how vaccine …

Recent advances in both theory and methods have created opportunities to simulate
biomolecular processes more efficiently using adaptive ensemble simulations. Ensemble-based …

Background: Tularemia is a potential biological weapon due to its high infectivity and ease
of dissemination. This study aimed to characterize the innate and adaptive responses …

Herpes simplex virus 1 (HSV-1) and HSV-2 are large, double-stranded DNA viruses that
cause lifelong persistent infections characterized by periods of quiescence and recurrent …

Background There are limited data regarding immunological correlates of protection for the
modified vaccinia Ankara (MVA) smallpox vaccine. Methods A total of 523 vaccinia-naive …

The immune response to live-attenuated Francisella tularensis vaccine and its host evasion
mechanisms are incompletely understood. Using RNA-Seq and LC–MS on samples …