Endothelial cells transduce mechanical forces from blood flow into intracellular signals
required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to …

Differences in global levels of histone acetylation occur in normal and cancer cells, although
the reason why cells regulate these levels has been unclear. Here we demonstrate a role …

Hephaestin (Hp) plays an important role in intestinal iron absorption and is predicted to be a
ferroxidase based on significant sequence identity to the serum multicopper ferroxidase …

Skeletal aging is a complex process, characterized by a decrease in bone formation, an
increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a heterochromatin mark, …

Limited knowledge of the mechanisms that govern the self-renewal of human haematopoietic
stem cells (HSCs), and why this fails in culture, have impeded the expansion of HSCs for …

Gene activation in metazoans is accompanied by the presence of histone variants H2AZ and
H3.3 within promoters and enhancers. It is not known, however, what protein deposits H3.3 …

Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions
with the host lysine acetylases p300/CBP and the tumor suppressor RB. How these …

Copper and iron metabolism intersect in mammals. Copper deficiency simultaneously leads
to decreased iron levels in some tissues and iron deficiency anemia, whereas it results in …

Hephaestin is a membrane-bound multicopper ferroxidase necessary for iron egress from
intestinal enterocytes into the circulation. Mice with sex-linked anemia (sla) have a mutant …

Metazoan chromosomes are sequentially partitioned into topologically associating domains
(TADs) and then into smaller sub-domains. One class of sub-domains, insulated …