[HTML][HTML] Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization
JR Skinner, TM Shew, DM Schwartz, A Tzekov… - Journal of biological …, 2009 - ASBMB
Fatty acid-induced triacylglycerol synthesis produces triacylglycerol droplets with a protein
coat that includes perilipin 3/TIP47 and perilipin 4/S3-12. This study addresses the following …
coat that includes perilipin 3/TIP47 and perilipin 4/S3-12. This study addresses the following …
Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice
…, A Kovacs, CJ Weinheimer, TM Shew… - Nature …, 2020 - nature.com
The myocardium is metabolically flexible; however, impaired flexibility is associated with
cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial …
cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial …
[HTML][HTML] Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism
Objective The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for
treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis (NASH). We …
treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis (NASH). We …
Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21
LALS Harris, JR Skinner, TM Shew, TA Pietka… - Diabetes, 2015 - Am Diabetes Assoc
Perilipin 5 (PLIN5) is a lipid droplet protein and is highly expressed in oxidative tissue.
Expression of the PLIN5 gene is regulated by peroxisome proliferator–activated receptor-α, fasting…
Expression of the PLIN5 gene is regulated by peroxisome proliferator–activated receptor-α, fasting…
[HTML][HTML] CD36 Deficiency Impairs the Small Intestinal Barrier and InducesáSubclinical Inflammation in Mice
…, NH Son, BT Saunders, TA Pietka, TM Shew… - Cellular and molecular …, 2017 - Elsevier
Background & Aims CD36 has immunometabolic actions and is abundant in the small
intestine on epithelial, endothelial, and immune cells. We examined the role of CD36 in gut …
intestine on epithelial, endothelial, and immune cells. We examined the role of CD36 in gut …
Perilipin 1 moves between the fat droplet and the endoplasmic reticulum
JR Skinner, LALS Harris, TM Shew, NA Abumrad… - Adipocyte, 2013 - Taylor & Francis
Perilipin 1, unlike the other perilipins, is thought to be restricted to the fat droplet. We reassessed
its cellular distribution using the fat droplet marker CGI-58 in OP9 and 3T3-L1 adipocyte …
its cellular distribution using the fat droplet marker CGI-58 in OP9 and 3T3-L1 adipocyte …
Monoacylglycerol O‐acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice
JM Singer, TM Shew, D Ferguson, MK Renkemeyer… - …, 2022 - Wiley Online Library
Objective Monoacylglycerol O‐acyltransferase 1 (Mogat1), a lipogenic enzyme that converts
monoacylglycerol to diacylglycerol, is highly expressed in adipocytes and may regulate …
monoacylglycerol to diacylglycerol, is highly expressed in adipocytes and may regulate …
Mitochondrial pyruvate carrier inhibition in hepatic stellate cells attenuates fibrosis in nonalcoholic steatohepatitis in mice
…, M Habibi, SJ Eichler, A LaPoint, TM Shew, M He… - bioRxiv, 2023 - biorxiv.org
Hepatic stellate cells (HSC) are non-parenchymal cells within the liver that are the main drivers
of fibrosis in a variety of diseases of the liver. Upon liver injury, HSC can transdifferentiate …
of fibrosis in a variety of diseases of the liver. Upon liver injury, HSC can transdifferentiate …
[HTML][HTML] Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1
…, JM Singer, TM Shew, MR Martino, AM Hall, M He… - Molecular …, 2021 - Elsevier
Objective Monoacylglycerol acyltransferase (MGAT) enzymes catalyze the synthesis of
diacylglycerol from monoacylglycerol. Previous work has suggested the importance of MGAT …
diacylglycerol from monoacylglycerol. Previous work has suggested the importance of MGAT …
[HTML][HTML] A single centrifugation method for isolating fat droplets from cells and tissues
LALS Harris, TM Shew, JR Skinner, NE Wolins - Journal of lipid research, 2012 - ASBMB
Fat droplets (FDs) have important roles in cellular energy regulation. Isolating FDs from either
cells or tissue continues to be important for studying these organelles. Here, we describe a …
cells or tissue continues to be important for studying these organelles. Here, we describe a …