Human pesticide exposure can occur both occupationally and environmentally during
manufacture and after the application of indoor and outdoor pesticides, as well as through …

Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer
treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein 1 . …

Approximately 30% of human lung cancers acquire mutations in either Keap1 or Nfe2l2,
resulting in the stabilization of Nrf2, the Nfe2l2 gene product, which controls oxidative …

Despite mounting evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
engagement with immune cells, most express little, if any, of the canonical receptor of …

10.7554/eLife.28083.001 During tumorigenesis, the high metabolic demand of cancer cells
results in increased production of reactive oxygen species. To maintain oxidative …

Rewiring of metabolic pathways is a hallmark of tumorigenesis as cancer cells acquire
novel nutrient dependencies to support oncogenic growth. A major genetic subtype of lung …

Lymphatic transport maintains homeostatic health and is necessary for immune surveillance,
and yet lymphatic growth is often associated with solid tumour development and …

The biological and therapeutic implications of gene fusions in SCLC, an aggressive metastatic
lung cancer, are unknown. Our study investigates the functional significance of the in-…

Knowledge of fundamental differences between breast cancer subtypes has driven
therapeutic advances; however, basal-like breast cancer (BLBC) remains clinically intractable. …

Lung cancer treatment has benefited greatly through advancements in immunotherapies.
However, immunotherapy often fails in patients with specific mutations like KEAP1, which are …