T cells are important for effective viral clearance, elimination of virus-infected cells, and long-term
disease protection. To examine the full spectrum of CD8 + T cell immunity in COVID-19…

CD8 + T cell reactivity towards tumor mutation-derived neoantigens is widely believed to
facilitate the antitumor immunity induced by immune checkpoint blockade (ICB). Here we show …

Human endogenous retroviruses (HERV) form a substantial part of the human genome, but
mostly remain transcriptionally silent under strict epigenetic regulation, yet can potentially be …

Narcolepsy Type 1 (NT1) is a neurological sleep disorder, characterized by the loss of
hypocretin/orexin signaling in the brain. Genetic, epidemiological and experimental data support …

The peptide-dependent stability of MHC class I molecules poses a substantial challenge for
their use in peptide-MHC multimer–based approaches to comprehensively analyze T cell …

Background The cysteine proteinase legumain is highly expressed in cancer. Legumain is a
potential biomarker and has been suggested to be utilised for prodrug activation in cancer …

Prominent tasks of cysteine cathepsins involve endo-lysosomal proteolysis and turnover of
extracellular matrix constituents or plasma membrane proteins for maintenance of intestinal …

Patients with hematological malignancies are prioritized for COVID-19 vaccine due to their
high risk for severe SARS-CoV-2 infection-related disease and mortality. To understand T cell …

Proteases play essential roles in protein degradation, protein processing, and extracellular
matrix remodeling in all cell types and tissues. They are also involved in protein turnover for …

Background Adoptive cell therapy (ACT) has shown promising results for the treatment of
cancer and viral infections. Successful ACT relies on ex vivo expansion of large numbers of …