Activin A directs striatal projection neuron differentiation of human pluripotent stem cells

…, A Heuer, MA Ungless, TA Rodríguez… - …, 2015 - journals.biologists.com
The efficient generation of striatal neurons from human embryonic stem cells (hESCs) and
induced pluripotent stem cells (hiPSCs) is fundamental for realising their promise in disease …

Cell competition: the winners and losers of fitness selection

S Bowling, K Lawlor, TA Rodríguez - Development, 2019 - journals.biologists.com
The process of cell competition results in the elimination of cells that are viable but ‘less fit’
than surrounding cells. Given the highly heterogeneous nature of our tissues, it seems …

Nodal signalling in the epiblast patterns the early mouse embryo

J Brennan, CC Lu, DP Norris, TA Rodriguez… - Nature, 2001 - nature.com
Shortly after implantation the mouse embryo comprises three tissue layers. The founder
tissue of the embryo proper, the epiblast, forms a radially symmetric cup of epithelial cells that …

[HTML][HTML] P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development

…, JP Martinez-Barbera, J Gil, TA Rodríguez - Nature …, 2018 - nature.com
Ensuring the fitness of the pluripotent cells that will contribute to future development is important
both for the integrity of the germline and for proper embryogenesis. Consequently, it is …

The meiotic checkpoint monitoring sypapsis eliminates spermatocytes via p53-independent apoptosis

T Odorisio, TA Rodriguez, EP Evans, AR Clarke… - Nature …, 1998 - nature.com
Evidence is accumulating that meiosis is subject to ‘checkpoints’ that monitor the quality of
this complex process. In yeast unresolved double strand breaks (DSBs) in DNA are thought to …

[PDF][PDF] HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death

…, JP Martinez-Barbera, J Silke, TA Rodriguez… - Cell reports, 2014 - cell.com
Linear ubiquitination is crucial for innate and adaptive immunity. The linear ubiquitin chain
assembly complex (LUBAC), consisting of HOIL-1, HOIP, and SHARPIN, is the only known …

[PDF][PDF] Competitive interactions eliminate unfit embryonic stem cells at the onset of differentiation

…, S Pozzi, JM Sánchez, B Pernaute, TA Rodríguez - Developmental cell, 2013 - cell.com
A fundamental question in developmental biology is whether there are mechanisms to detect
stem cells with mutations that, although not adversely affecting viability, would compromise …

BMP signalling inhibits premature neural differentiation in the mouse embryo

…, LA Crompton, J Godwin, Y Mishina, TA Rodriguez - 2007 - journals.biologists.com
The specification of a subset of epiblast cells to acquire a neural fate constitutes the first step
in the generation of the nervous system. Little is known about the signals required for neural …

[PDF][PDF] Cell competition and its role in the regulation of cell fitness from development to cancer

A Di Gregorio, S Bowling, TA Rodriguez - Developmental cell, 2016 - cell.com
Cell competition is a cell fitness-sensing mechanism conserved from insects to mammals
that eliminates those cells that, although viable, are less fit than their neighbors. An important …

[HTML][HTML] Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis

SL Dunwoodie, TA Rodriguez… - Mechanisms of …, 1998 - Elsevier
Msg1 and Mrg1 are founding members of a gene family which exhibit distinct patterns of
gene expression during mouse embryogenesis. Sequence analysis reveals that these genes …