Innate immune cell activation causes lung fibrosis in a humanized model of long COVID
L Cui, Z Fang, CM De Souza, T Lerbs… - Proceedings of the …, 2023 - National Acad Sciences
COVID-19 remains a global pandemic of an unprecedented magnitude with millions of people
now developing “COVID lung fibrosis.” Single-cell transcriptomics of lungs of patients with …
now developing “COVID lung fibrosis.” Single-cell transcriptomics of lungs of patients with …
JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models
…, JT Garcia, M Januszyk, M King, T Lerbs… - Science translational …, 2021 - science.org
Pathologic skin scarring presents a vast economic and medical burden. Unfortunately, the
molecular mechanisms underlying scar formation remain to be elucidated. We used a …
molecular mechanisms underlying scar formation remain to be elucidated. We used a …
[HTML][HTML] Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
The transcription factor JUN is highly expressed in pulmonary fibrosis. Its induction in mice
drives lung fibrosis, which is abrogated by administration of anti-CD47. Here, we use high-…
drives lung fibrosis, which is abrogated by administration of anti-CD47. Here, we use high-…
[HTML][HTML] Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
…, A Salhotra, RE Jones, A Burcham, T Lerbs… - Nature …, 2020 - nature.com
Adhesions are fibrotic scars that form between abdominal organs following surgery or
infection, and may cause bowel obstruction, chronic pain, or infertility. Our understanding of …
infection, and may cause bowel obstruction, chronic pain, or infertility. Our understanding of …
[HTML][HTML] CD47 prevents the elimination of diseased fibroblasts in scleroderma
T Lerbs, L Cui, ME King, T Chai, C Muscat, L Chung… - JCI insight, 2020 - ncbi.nlm.nih.gov
Scleroderma is a devastating fibrotic autoimmune disease. Current treatments are partly
effective in preventing disease progression but do not remove fibrotic tissue. Here, we …
effective in preventing disease progression but do not remove fibrotic tissue. Here, we …
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors
L Cui, I Moraga, T Lerbs, C Van Neste… - Proceedings of the …, 2021 - National Acad Sciences
Thrombopoietin (TPO) and the TPO-receptor (TPO-R, or c-MPL) are essential for hematopoietic
stem cell (HSC) maintenance and megakaryocyte differentiation. Agents that can …
stem cell (HSC) maintenance and megakaryocyte differentiation. Agents that can …
Overexpression of SIX1 is an independent prognostic marker in stage I–III colorectal cancer
C Kahlert, T Lerbs, M Pecqueux… - … journal of cancer, 2015 - Wiley Online Library
Epithelial‐to‐mesenchymal transition (EMT) contributes significantly to tumor progression and
metastasis. The assessment of EMT‐associated transcription factors could be a promising …
metastasis. The assessment of EMT‐associated transcription factors could be a promising …
[HTML][HTML] Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer
Background Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC)
contribute to tumour progression and metastasis. Assessment of transcription factors involved in …
contribute to tumour progression and metastasis. Assessment of transcription factors involved in …
[PDF][PDF] Expansion of bone precursors through jun as a novel treatment for osteoporosis-associated fractures
T Lerbs, L Cui, C Muscat, A Saleem, C Van Neste… - Stem Cell Reports, 2020 - cell.com
Osteoporosis and osteoporotic fractures lead to decreased life quality and high healthcare
costs. Current treatments prevent losses in bone mass and fractures to some extent but have …
costs. Current treatments prevent losses in bone mass and fractures to some extent but have …
Multi-Omics Profiling of Skin Biopsies of Patients with Sclerodermatous Graft-Vs-Host Disease Suggests Therapeutic Potential of Targeting Don't Eat Me Signals
L Cui, C De Souza, T Lerbs, J Poyser, C Yu, K Rieger… - Blood, 2022 - ashpublications.org
Introduction: Chronic graft-vs-host disease (cGVHD) is a major complication of allogeneic
hematopoietic stem cell transplantation (HCT). This debilitating, chronic condition is …
hematopoietic stem cell transplantation (HCT). This debilitating, chronic condition is …