Neurogenesis occurs continuously in the forebrain of adult mammals, but the functional
importance of adult neurogenesis is still unclear. Here, using a genetic labeling method in adult …

Calcineurin (CN), a calcium- and calmodulin-dependent protein phosphatase, plays a
significant role in the central nervous system. Previously, we reported that forebrain-specific CN …

Throughout life, new neurons are continuously added to the dentate gyrus. As this continuous
addition remodels hippocampal circuits, computational models predict that neurogenesis …

Trisomy 21 results in Down's syndrome, but little is known about how a 1.5-fold increase in
gene dosage produces the pleiotropic phenotypes of Down's syndrome. Here we report that …

Although the mouse genome is now completely sequenced, the functions of most of the
genes expressed in the brain are not known. The influence of a given gene on a specific …

The use of mice as animal models has long been considered essential in modern biomedical
research, but the role of mouse models in research was challenged by a recent report that …

Calcineurin is a calcium-dependent protein phosphatase that has been implicated in various
aspects of synaptic plasticity. By using conditional gene-targeting techniques, we created …

Substantial evidence suggests that chromosomal abnormalities contribute to the risk of
autism. The duplication of human chromosome 15q11-13 is known to be the most frequent …

Members of the muscarinic acetylcholine receptor family (M1–M5) have central roles in the
regulation of many fundamental physiological functions 1 , 2 . Identifying the specific receptor …

Members of the muscarinic acetylcholine receptor family are thought to play key roles in the
regulation of a large number of important functions of the CNS. However, the precise roles of …