Abnormal glucose metabolism and enhanced oxidative stress accelerate cardiovascular
disease, a chronic inflammatory condition causing high morbidity and mortality. Here, we report …

Aicardi-Goutières syndrome (AGS) is a rare, genetically determined early-onset progressive
encephalopathy. To date, mutations in six genes have been identified as etiologic for AGS. …

Antiviral treatments targeting the coronavirus disease 2019 are urgently required. We
screened a panel of already approved drugs in a cell culture model of severe acute respiratory …

The spectrum of vascular inflammatory disease ranges from atherosclerosis and hypertension,
widespread conditions affecting large proportions of the population, to the vasculitides, …

Immune aging results in progressive loss of both protective immunity and T cell–mediated
suppression, thereby conferring susceptibility to a combination of immunodeficiency and …

Objective To elucidate the genetic background of a patient with neonatal‐onset multisystem
inflammatory disease (NOMID) with no NLRP3 mutation. Methods A Japanese male child …

M-protease is a subtilisin-family serine protease produced by an alkaliphilic Bacillus sp.
strain. Optimal enzymatic activity of the protein occurs at pH 12.3. The crystal structure of M-…

Antiviral treatments targeting the emerging coronavirus disease 2019 (COVID-19) are
urgently required. We screened a panel of already-approved drugs in a cell culture model of …

Two normally occurring polymorphisms of the human PRNP gene, methionine (M)/valine (V)
at codon 129 and glutamic acid (E)/lysine (K) at codon 219, can affect the susceptibility to …

Patients with coronary artery disease (CAD) are at high risk for reactivation of the varicella
zoster virus (VZV) and development of herpes zoster (HZ). Here, we found that macrophages …