Translation arrest by polybasic sequences induces ribosome stalling, and the arrest product
is degraded by the ribosome-mediated quality control (RQC) system. Here we report that …

FUS is an RNA/DNA-binding protein involved in multiple steps of gene expression and is
associated with amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration (…

Translational control of mRNAs in dendrites is essential for certain forms of synaptic plasticity
and learning and memory. CPEB is an RNA-binding protein that regulates local translation …

Ribosome movement is not always smooth and is rather often impeded. For ribosome
pauses, fundamental issues remain to be addressed, including where ribosomes pause on …

Fragile X syndrome (FXS), the most common cause of inherited mental retardation and autism,
is caused by transcriptional silencing of FMR1, which encodes the translational repressor …

MicroRNAs (miRNAs) are small, noncoding RNAs that inhibit translation and promote
mRNA decay. The levels of mature miRNAs are the result of different rates of transcription, …

In eubacteria, the dissociation of the 70 S ribosome into the 30 S and 50 S subunits is the
essential first step for the translation initiation of canonical mRNAs that possess 5′-leader …

Fused in sarcoma (FUS) and splicing factor, proline- and glutamine-rich (SFPQ) are RNA
binding proteins that regulate RNA metabolism. We found that alternative splicing of the Mapt …

In eukaryotic translation initiation, the eIF2·GTP/Met‐tRNA i Met ternary complex (TC) binds
the eIF3/eIF1/eIF5 complex to form the multifactor complex (MFC), whereas eIF2·GDP binds …

FUS is an RNA-binding protein associated with frontotemporal lobar degeneration (FTLD)
and amyotrophic lateral sclerosis (ALS). Previous reports have demonstrated intrinsic roles of …