Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence indicates
that the mitral valve is not a passive structure, but—even in adult life—remains dynamic …

We propose, here, an FT-IR method to monitor the spontaneous differentiation of murine
embryonic stem (ES) cells in their early development. Principal component analysis and …

Genetically modified mice have advanced our understanding of valve development and
disease. Yet, human pathophysiological valvulogenesis remains poorly understood. Here we …

2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) causes abnormalities during heart
development. Cardiomyocytes derived from embryonic stem (ES) cells are a robust model for the …

A recent remarkable study has shown that when mouse NIH-3T3 fibroblasts are exposed to
an embryonic stem cell (ESC) extract, the majority of them expresses the Oct-4 gene, form …

As recently pointed out in the literature, Fourier transform infrared (FT-IR) spectroscopy is
emerging as a powerful tool in stem cell research. In this work we characterized in situ by FT-IR …

Human Embryonic or pluripotent stem cells hold many promises in regenerative medicine.
They also provide the scientific community with powerful models of early human development …

Published clinical trials in patients with ischemic diseases show limited benefit of adult stem
cell-based therapy, likely due to their restricted plasticity and commitment toward vascular …

Autosomal recessive osteopetrosis is a human bone disease mainly caused by TCIRG1
gene mutations that prevent osteoclasts resorbing activity, recapitulated by the oc/oc mouse …

Human embryonic stem (HES) cells are pluripotent and give rise to any cell lineage. More
specifically, how the first embryonic lineage (ie, cardiac lineage) is acquired remains in many …