A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

The prevalence of dementia in the Western world in people over the age of 60 has been
estimated to be greater than 5%, about two-thirds of which are due to Alzheimer’s disease 1 , 2 , …

Common variant genome-wide association studies (GWASs) have, to date, identified >24
risk loci for Parkinson's disease (PD). To discover additional loci, we carried out a GWAS …

Genome‐wide scans of nucleotide variation in human subjects are providing an increasing
number of replicated associations with complex disease traits. Most of the variants detected …

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans
has been accumulating over the last decade, in particular a large number of loci derived from …

Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a
range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ∼8% of the …

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using Immunochip …

Despite significant progress in the identification of genetic loci for age-related macular
degeneration (AMD), not all of the heritability has been explained. To identify variants which …

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe …