Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone disorder
adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R and …

Cushing's syndrome is an endocrine disorder caused by excess production of the stress
hormone cortisol. Precision medicine strategies have identified single allele mutations within …

Adrenal Cushing’s syndrome is a disease of cortisol hypersecretion often caused by mutations
in protein kinase A catalytic subunit (PKAc). Using a personalized medicine screening …

Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone
disorder adrenal Cushing’s syndrome. Here we define mechanisms of action for the PKAc-L205R …

The study investigated the effects of locus of control beliefs as an individual difference
variable on (a) the relationship between negative life events and psychological disorder,(b) …

Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research
and therapy, ranging from the identification of the first specific chromosomal abnormality …

Background: Hepatocellular carcinoma is a heterogeneous tumor that accumulates mutational
burden and dysregulated signaling pathways that differ from early to advanced stage. …

Oomycetes in the class Saprolegniomycetidae of the Eukaryotic kingdom Stramenopila
have evolved as severe pathogens of amphibians, crustaceans, fish and insects, resulting in …

Background. Optimized conditions for survival and function of human islets must be defined
if sufficient islets are to be recovered from a single human donor pancreas to reverse type-1 …

A major obstacle to development of subunit vaccines and diagnostic reagents for tuberculosis
is the inability to produce large quantities of these proteins. To test the hypothesis that …