User profiles for Tyler Matheny
 | Tyler MathenySOPHiA GENETICS Verified email at sophiagenetics.com Cited by 2322 |
Distinct stages in stress granule assembly and disassembly
10.7554/eLife.18413.001 Stress granules are non-membrane bound RNA-protein (RNP)
assemblies that form when translation initiation is limited and contain a biphasic structure with …
assemblies that form when translation initiation is limited and contain a biphasic structure with …
[PDF][PDF] The stress granule transcriptome reveals principles of mRNA accumulation in stress granules
Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress
granules are important in the stress response and may contribute to some degenerative …
granules are important in the stress response and may contribute to some degenerative …
RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome
…, DSW Protter, T Matheny… - Proceedings of the …, 2018 - National Acad Sciences
Stress granules are higher order assemblies of nontranslating mRNAs and proteins that
form when translation initiation is inhibited. Stress granules are thought to form by protein–…
form when translation initiation is inhibited. Stress granules are thought to form by protein–…
Identification of NAD+ capped mRNAs in Saccharomyces cerevisiae
RW Walters, T Matheny, LS Mizoue… - Proceedings of the …, 2017 - National Acad Sciences
RNAs besides tRNA and rRNA contain chemical modifications, including the recently
described 5′ nicotinamide-adenine dinucleotide (NAD + ) RNA in bacteria. Whether 5′ NAD-…
described 5′ nicotinamide-adenine dinucleotide (NAD + ) RNA in bacteria. Whether 5′ NAD-…
[PDF][PDF] RNase L reprograms translation by widespread mRNA turnover escaped by antiviral mRNAs
In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR)
and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR inhibits …
and ribonuclease L (RNase L) reprogram translation in mammalian cells. PKR inhibits …
RNA partitioning into stress granules is based on the summation of multiple interactions
Stress granules (SGs) are stress-induced RNA–protein assemblies formed from a complex
transcriptome of untranslating ribonucleoproteins (RNPs). Although RNAs can be either …
transcriptome of untranslating ribonucleoproteins (RNPs). Although RNAs can be either …
Transcriptome-wide comparison of stress granules and P-bodies reveals that translation plays a major role in RNA partitioning
The eukaryotic cytosol contains multiple RNP granules, including P-bodies and stress
granules. Three different methods have been used to describe the transcriptome of stress …
granules. Three different methods have been used to describe the transcriptome of stress …
[HTML][HTML] Limited effects of m6A modification on mRNA partitioning into stress granules
The presence of the m 6 A modification in mammalian mRNAs is proposed to promote mRNA
recruitment to stress granules through the interaction with YTHDF proteins. We test this …
recruitment to stress granules through the interaction with YTHDF proteins. We test this …
[PDF][PDF] Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression
AE Campbell, MC Dyle, R Albanese, T Matheny… - Cell reports, 2023 - cell.com
Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination
codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However, …
codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However, …
Isolation of mammalian stress granule cores for RNA-Seq analysis
Stress granules are dynamic, conserved non-translating RNA-protein assemblies that form
during cellular stress and are related to pathological aggregates in many neurodegenerative …
during cellular stress and are related to pathological aggregates in many neurodegenerative …