Since the publication of the Wellcome Trust Case Control Consortium (WTCCC) landmark
study a decade ago, genome-wide association studies (GWAS) have led to the discovery of …

Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

Inflammatory bowel diseases [IBD] are a heterogeneous spectrum with two extreme
phenotypes, Crohn’s disease [CD] and ulcerative colitis [UC], which both represent numerous …

Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and CD27 (double
negative; DN). We show that DN cell expansions reflected a subset of CXCR5 - CD11c + …

Background Stricturing and penetrating complications account for substantial morbidity and
health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict …

While many disease-associated variants have been identified through genome-wide association
studies, their downstream molecular consequences remain unclear. To identify these …

Ancient genomic sequences have started to reveal the origin and the demographic impact
of farmers from the Neolithic period spreading into Europe 1 , 2 , 3 . The adoption of farming, …

Expression quantitative trait locus analysis has emerged as an important component of efforts
to understand how genetic polymorphisms influence disease risk and is poised to make …

Genome-wide association studies (GWAS) have detected many disease associations. However,
the reported variants tend to explain small fractions of risk, and there are doubts about …

The Romani, the largest European minority group with approximately 11 million people [1],
constitute a mosaic of languages, religions, and lifestyles while sharing a distinct social …