Nitric oxide (NO) has been invoked as an important pathogenic factor in a wide range of
immunologically mediated diseases. The present study demonstrates that macrophage-derived …

An unusual group of carcinomas, here termed nuclear protein in testis (NUT) midline
carcinomas (NMC), are characterized by translocations that involve NUT, a novel gene on …

… Hoffmann K, Firth MJ, Freitas JR, de Klerk NH, Kees UR: Gene expression levels in small
specimens from patients detected using oligonucleotide arrays. Mol Biotech. … Ursula R Kees …

Connective tissue growth factor (CTGF/CCN2) has long been associated with human cancers.
The role it plays in these neoplasms is diverse and tumour specific. Recurring patterns in …

A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14)
(q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this …

Germ-line RB-1 mutations predispose to pineoblastoma (PinB), but other predisposing genetic
factors are not well established. We recently identified a germ-line DICER1 mutation in a …

We report here a rare case of intrathoracic undifferentiated carcinoma in an 11-year-old girl.
The biopsy tissue stained with antibodies against cytokeratin and carcinoembryonic antigen. …

Cell line models of glucocorticoid resistance in childhood acute lymphoblastic leukemia (ALL)
almost invariably exhibit altered glucocorticoid receptor (GR) function. However, these …

The cells of solid tumours are known to have an altered metabolism, with high rates of glucose
uptake and glycolysis, which results in the excessive production of lactate. To date there …

p53 mutations have been reported in cell lines derived from relapsed neuroblastoma tumors.
We hypothesize that functional inactivation of p53 by mutation or other mechanisms is …