Obesity and asthma
… Author links open overlay panel Ubong Peters PhD a , Anne E. Dixon MA, BM, BCh a , Erick
… List of Design Committee Members: Ubong Peters, PhD, Anne E. Dixon, MA, BM, BCh, and …
… List of Design Committee Members: Ubong Peters, PhD, Anne E. Dixon, MA, BM, BCh, and …
The effect of obesity on lung function
AE Dixon, U Peters - Expert review of respiratory medicine, 2018 - Taylor & Francis
Introduction: There is a major epidemic of obesity, and many obese patients suffer with
respiratory symptoms and disease. The overall impact of obesity on lung function is multifactorial, …
respiratory symptoms and disease. The overall impact of obesity on lung function is multifactorial, …
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes
Context Continuing advances in genotyping technologies and the inclusion of DNA collection
in observational studies have resulted in an increasing number of genetic association …
in observational studies have resulted in an increasing number of genetic association …
K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions
Somatic mutations in the small GTPase K-Ras are the most common activating lesions found
in human cancer, and are generally associated with poor response to standard therapies 1 …
in human cancer, and are generally associated with poor response to standard therapies 1 …
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …
[HTML][HTML] Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for …
…, M Just, N Harbeck, C Schumacher, U Peters… - Annals of …, 2021 - Elsevier
Background In the phase III IMpassion130 trial, combining atezolizumab with first-line
nanoparticle albumin-bound-paclitaxel for advanced triple-negative breast cancer (aTNBC) …
nanoparticle albumin-bound-paclitaxel for advanced triple-negative breast cancer (aTNBC) …
Genetic analyses of diverse populations improves discovery for complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …
biology of complex traits, drug development and clinical guidelines. However, the majority …
Detectable clonal mosaicism and its relationship to aging and cancer
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide
association studies, we observed large chromosomal abnormalities in a subset of clones in …
association studies, we observed large chromosomal abnormalities in a subset of clones in …
[PDF][PDF] Targeting KRAS mutant cancers with a covalent G12C-specific inhibitor
MR Janes, J Zhang, LS Li, R Hansen, U Peters, X Guo… - Cell, 2018 - cell.com
KRAS G12C was recently identified to be potentially druggable by allele-specific covalent
targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this …
targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this …
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
…, Y Zhou, S Calderari, J Van Rooij, C Carlson, U Peters… - Nature, 2015 - nature.com
The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF
≤ 1%) variants contribute to complex traits and disease in the general population is …
≤ 1%) variants contribute to complex traits and disease in the general population is …