Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component.
To identify novel loci associated with hip OA we performed a meta-analysis of genome…

We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome
10q 1 . We genotyped 228 microsatellite markers in Icelandic individuals with type 2 …

Obesity results from the interaction of genetic and environmental factors. To search for sequence
variants that affect variation in two common measures of obesity, weight and body mass …

Common human diseases result from the interplay of many genes and environmental factors.
Therefore, a more integrative biology approach is needed to unravel the complexity and …

We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases
and controls, and we found that a previously described variant in the transcription factor 7-…

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Background Bone mineral density influences the risk of osteoporosis later in life and is useful
in the evaluation of the risk of fracture. We aimed to identify sequence variants associated …

Detailed knowledge of how diversity in the sequence of the human genome affects phenotypic
diversity depends on a comprehensive and reliable characterization of both sequences …

The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF
≤ 1%) variants contribute to complex traits and disease in the general population is …

Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism,
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …