User profiles for U.L. Mallimadugula
 | Upasana L. MallimadugulaWashington University in St. Louis Verified email at wustl.edu Cited by 303 |
Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms
…, JJ Miller, UL Mallimadugula… - Proceedings of the …, 2023 - National Acad Sciences
The ε4-allele variant of apolipoprotein E (ApoE4) is the strongest genetic risk factor for
Alzheimer’s disease, although it only differs from its neutral counterpart ApoE3 by a single amino …
Alzheimer’s disease, although it only differs from its neutral counterpart ApoE3 by a single amino …
[PDF][PDF] Citizen scientists create an exascale computer to combat COVID-19
The SARS-CoV-2/COVID-19 pandemic continues to threaten global health and socioeconomic
stability. Experiments have revealed snapshots of many of the viral components but …
stability. Experiments have revealed snapshots of many of the viral components but …
[HTML][HTML] SARS-CoV-2 simulations go exascale to capture spike opening and reveal cryptic pockets across the proteome
SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression,
and replication, which depend on the structure and dynamics of its constituent proteins. …
and replication, which depend on the structure and dynamics of its constituent proteins. …
Opening of a cryptic pocket in β-lactamase increases penicillinase activity
CR Knoverek, UL Mallimadugula… - Proceedings of the …, 2021 - National Acad Sciences
Understanding the functional role of protein-excited states has important implications in protein
design and drug discovery. However, because these states are difficult to find and study, …
design and drug discovery. However, because these states are difficult to find and study, …
Parallel path mechanisms lead to nonmonotonic force-velocity curves and an optimum load for molecular motor function
UL Mallimadugula, EA Galburt - Physical Review E, 2022 - APS
Molecular motors convert chemical potential energy into mechanical work and perform a
great number of critical biological functions. Examples include the polymerization and …
great number of critical biological functions. Examples include the polymerization and …
Do differences in cryptic pocket opening control functional tradeoffs in filovirus immune evasion?
… We hypothesize that the sequence differences between these homologs lead to differing
pocket dynamics that ultimately lead to a preference for 50-ppp ends for REBOV and ZEBOV …
pocket dynamics that ultimately lead to a preference for 50-ppp ends for REBOV and ZEBOV …
FRET not! msmFRET reveals the kinetic conformational heterogeneity within single molecule FRET distributions
J Miller, UL Mallimadugula, MI Zimmerman… - Biophysical …, 2024 - cell.com
Understanding protein conformational ensembles and dynamics affords critical mechanistic
insight into protein function and enables rational drug design. Unfortunately, it is often …
insight into protein function and enables rational drug design. Unfortunately, it is often …
Single-molecule spectroscopy of Apolipoprotein E reveals a complex conformational ensemble
The ε4-allele variant of Apolipoprotein E (ApoE4) is the strongest genetic risk factor for
Alzheimer's disease, though it only differs from its neutral counterpart ApoE3 by a single amino …
Alzheimer's disease, though it only differs from its neutral counterpart ApoE3 by a single amino …
Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms
…, MI Zimmerman, JJ Miller, UL Mallimadugula… - bioRxiv, 2022 - biorxiv.org
The ε4-allele variant of Apolipoprotein E (ApoE4) is the strongest genetic risk factor for
Alzheimer’s disease, though it only differs from its neutral counterpart ApoE3 by a single amino …
Alzheimer’s disease, though it only differs from its neutral counterpart ApoE3 by a single amino …
[PDF][PDF] A Parallel Ratchet-Stroke Mechanism Leads to an Optimum Force for Molecular Motor Function
UL Mallimadugula, EA Galburt - Biophysical Journal, 2021 - cell.com
Molecular motors convert chemical potential energy into mechanical work and perform a
great number of critical biological functions. Examples include the polymerization and …
great number of critical biological functions. Examples include the polymerization and …