The increasing threat of pathogen resistance to antibiotics requires the development of novel
antimicrobial strategies. Here we present a proof of concept for a genetic strategy that aims …

We show that phage lysogenization, lysogens, and prophage induction are all targeted by
CRISPR. The results demonstrate that genomic DNA is not immune to the CRISPR system, …

The clustered regularly interspaced short palindromic repeats and their associated proteins (CRISPR/Cas)
constitute a recently identified prokaryotic defense mechanism against …

The elimination of viruses and tumors by natural killer cells is mediated by specific natural
killer cell receptors. To study the in vivo function of a principal activating natural killer cell …

CRISPR–Cas (clustered, regularly interspaced short palindromic repeats coupled with
CRISPR-associated proteins) is a bacterial immunity system that protects against invading …

Microbiomes are vast communities of microorganisms and viruses that populate all natural
ecosystems. Viruses have been considered to be the most variable component of …

Lysis of virus-infected and tumor cells by NK cells is mediated via natural cytotoxicity receptors
(NCRs). We have recently shown that the NKp44 and NKp46 NCRs, but not the NKp30, …

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated
(Cas) proteins constitute an adaptive immune system in prokaryotes. The system …

Generating plants with increased yields while maintaining low production and maintenance
costs is highly important since plants are the major food source for humans and animals, as …

The extensive use of antibiotics over the last century has resulted in a significant artificial
selection pressure for antibiotic-resistant pathogens to evolve. Various strategies to fight these …