Several approaches have been described to fluorescently label and image DNA and chromatin
in situ on the single-molecule level. These superresolution microscopy techniques are …

During meiosis, homologous chromosomes associate to form the synaptonemal complex (SC),
a structure essential for fertility. Information about the epigenetic features of chromatin …

Background Cells detect and adapt to hypoxic and nutritional stress through immediate
transcriptional, translational and metabolic responses. The environmental effects of ischemia on …

Spatially modulated illumination (SMI) microscopy is a method of wide field fluorescence
microscopy featuring interferometric illumination, which delivers structural information about …

Advanced light microscopy is an important tool for nanostructure analysis of chromatin. In
this report we present a general concept for Single Molecule localization Microscopy (SMLM) …

We describe a versatile optical projection tomography system for rapid three-dimensional
imaging of microscopic specimens in vivo. Our tomographic setup eliminates the in xy and z …

The human genome has been decoded, but we are still far from understanding the regulation
of all gene activities. A largely unexplained role in these regulatory mechanisms is played …

The application of optical projection tomography to in-vivo experiments is limited by specimen
movement during the acquisition. We present a set of mathematical correction methods …

Understanding the positional and structural aspects of biological nanostructures simultaneously
is as much a challenge as a desideratum. In recent years, highly accurate (20 nm) …

This unique book on super-resolution microscopy techniques presents comparative, in-depth
analyses of the strengths and weaknesses of the individual approaches. It was written for …