The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1,
LSP1, and 2q35 confer increased risks of breast cancer for BRCA1 or BRCA2 mutation …

Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC)
susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and …

The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported
in single populations, with the majority of reports focused on White in Europe and North …

Peroxisome proliferator-activated receptors (PPARs) are pleiotropic regulators of growth
and differentiation of many cell types. We have performed a comprehensive analysis of the …

Purpose BRCA1/2 mutations increase the risk of breast and prostate cancer in men.
Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We …

The bulge region of adult murine hair follicles harbors epidermal stem cells with multipotent
capacity; however, the restricted contributions of these cells under homeostatic conditions …

Pain perception has evolved as a warning mechanism to alert organisms to tissue damage
and dangerous environments 1 , 2 . In humans, however, undesirable, excessive or chronic …

Ryanodine receptor 1 (RYR1) mutations are a common cause of congenital myopathies
associated with both dominant and recessive inheritance. Histopathological findings frequently …

Mutations in DNMT 3A, the gene encoding DNA methyltransferase 3 alpha, have been
identified as molecular drivers in acute myeloid leukaemia ( AML ) with possible implications for …

Alterations in specific signal transduction pathways may explain the increased expression
of proinflammatory cytokines seen in inflammatory diseases such as psoriasis. We reveal …