New discoveries in RNA biology underscore a need for chemical tools to clarify their roles in
pathophysiological mechanisms. In certain cancers, synthesis of the let-7 microRNA tumor …

For many decades, the design of new nucleoside analogs as potential therapeutic agents
focused on both sugar and nucleobase modifications. These nucleoside analogs rely on …

Acyclic nucleoside phosphonates (ANPs) are at the cornerstone of DNA virus and retrovirus
therapies. They reach their target, the viral DNA polymerase, after two phosphorylation steps …

The nascent peptide exit tunnel has recently been identified as a functional region of
ribosomes contributing to translation regulation and co-translational protein folding. Inducible …

In this study, we described the synthesis of 1,4- and 1,5-disubstituted-1,2,3-triazolo-nucleosides
from various alkynes with 1′-azido-2′,3′,5′-tri-O-acetylribose using either copper-…

Dead End (DND1) is an RNA-binding protein essential for germline development through
its role in post-transcriptional gene regulation. The molecular mechanisms behind selection …

A series of unsaturated acyclonucleoside bis(POC) prodrugs of E configuration were
synthesized through an expeditious, highly efficient and stereoselective one-step procedure from …

MicroRNAs (miRNAs) originate from stem-loop-containing precursors (pre-miRNAs, pri-miRNAs)
and mature by means of the Drosha and Dicer endonucleases and their associated …

In our on-going program targeting anti-pox activity, we report here the synthesis of hitherto
unknown acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key …

The conversion of selected β-d-2,6-diaminopurine nucleosides (DAPNs) to their phosphoramidate
prodrug (PD) substantially blocks the conversion to the G-analog allowing for the …