User profiles for Ulrich F Keyser

Ulrich F. Keyser

Professor of Applied Physics, Cavendish Lab, University of Cambridge
Verified email at cam.ac.uk
Cited by 15693

Salt dependence of ion transport and DNA translocation through solid-state nanopores

RMM Smeets, UF Keyser, D Krapf, MY Wu… - Nano …, 2006 - ACS Publications
We report experimental measurements of the salt dependence of ion transport and DNA
translocation through solid-state nanopores. The ionic conductance shows a three-order-of-…

Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores

NAW Bell, UF Keyser - Nature nanotechnology, 2016 - nature.com
The simultaneous detection of a large number of different analytes is important in bionanotechnology
research and in diagnostic applications. Nanopore sensing is an attractive method …

Controlling molecular transport through nanopores

UF Keyser - Journal of The Royal Society Interface, 2011 - royalsocietypublishing.org
Nanopores are emerging as powerful tools for the detection and identification of macromolecules
in aqueous solution. In this review, we discuss the recent development of active and …

Detecting DNA folding with nanocapillaries

…, O Otto, C Chimerel, J Gornall, UF Keyser - Nano …, 2010 - ACS Publications
We demonstrate for the first time the detection of the folding state of double-stranded DNA in
nanocapillaries with the resistive pulse technique. We show that glass capillaries can be …

Real-time deformability cytometry: on-the-fly cell mechanical phenotyping

…, A Jacobi, M Wobus, N Töpfner, UF Keyser… - Nature …, 2015 - nature.com
We introduce real-time deformability cytometry (RT-DC) for continuous cell mechanical
characterization of large populations (>100,000 cells) with analysis rates greater than 100 cells/s. …

[HTML][HTML] DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering

…, T Zhang, T Liedl, JJ Baumberg, UF Keyser - Nature …, 2014 - nature.com
Plasmonic sensors are extremely promising candidates for label-free single-molecule analysis
but require exquisite control over the physical arrangement of metallic nanostructures. …

[HTML][HTML] Direct force measurements on DNA in a solid-state nanopore

UF Keyser, BN Koeleman, S Van Dorp, D Krapf… - Nature Physics, 2006 - nature.com
Among the variety of roles for nanopores in biology, an important one is enabling polymer
transport, for example in gene transfer between bacteria 1 and transport of RNA through the …

[HTML][HTML] Origin of the electrophoretic force on DNA in solid-state nanopores

S Van Dorp, UF Keyser, NH Dekker, C Dekker… - Nature Physics, 2009 - nature.com
Despite gel electrophoresis being one of the main workhorses of molecular biology, the
physics of polyelectrolyte electrophoresis in a strongly confined environment remains poorly …

Noise in solid-state nanopores

RMM Smeets, UF Keyser… - Proceedings of the …, 2008 - National Acad Sciences
We study ionic current fluctuations in solid-state nanopores over a wide frequency range and
present a complete description of the noise characteristics. At low frequencies (f ≲ 100 Hz) …

DNA origami nanopores

…, M Ablay, G Divitini, C Ducati, T Liedl, UF Keyser - Nano …, 2012 - ACS Publications
We demonstrate the assembly of functional hybrid nanopores for single molecule sensing
by inserting DNA origami structures into solid-state nanopores. In our experiments, single …