Survival of all life fonns requires dynamic response to environmental change and challenge.
In higher organisms such phenomena include defensive reн sponse to stress, injury, viruses…

IκB-α inhibits transcription factor NF-κB by retaining it in the cytoplasm. Various stimuli, typically
those associated with stress or pathogens, rapidly inactivate IκB-α. This liberates NF-κB …

Gene expression profiling has revealed that diffuse large B cell lymphoma (DLBCL) consists
of at least two distinct diseases. Patients with one DLBCL subtype, termed activated B cell–…

NF-κB is a family of related, dimeric transcription factors that are readily activated in cells by
signals associated with stress or pathogens. These factors are critical to host defense, as …

LYMPHOCYTE migration from blood into tissue depends on integrin-mediated adhesion to
endothelium 1–4 . Adhesion requires not only integrin ligands on the endothelium, but also …

NF-κB is usually activated by signal-induced, ubiquitin-mediated degradation of its inhibitor,
IκB. This process is initiated by phosphorylation of IκB by the IκB kinase (IKK) complex, …

The variable portion of an immunoglobulin heavy chain gene is assembled from at least three
discontinuous segments of DNA, the V, D and J regions. We have characterized a 30 kb …

The NK-kappa B transcription factor complex is sequestered in the cytoplasm by the
inhibitory protein I kappa B-alpha (MAD-3). Various cellular stimuli relieve this inhibition by …

We present and review experiments that identify points of close approach of the RNA polymerase
to two promoters, lac UV5 and T7 A3. We identify the contacts to the phosphates along …

Bcl-3 is an IκB-related protein with ankyrin repeat motifs. Its gene is located at a site of
recurrent translocations in a subset of B cell chronic lymphocytic leukemias. Bcl-3 associates …