Frizzled receptors are components of the Wnt signalling pathway, but how they activate the
canonical Wnt/β‐catenin pathway is not clear. Here we use three distinct vertebrate frizzled …

Wnt signalling plays a crucial role in the control of morphogenetic movements. We describe
the expression and functional analyses of frizzled 7 (Xfz7) during gastrulation in Xenopus. …

The mesoderm of Xenopus laevis arises through an inductive interaction in which signals from
the vegetal hemisphere of the embryo act on overlying equatorial cells. One candidate for …

Wnt signaling has an important role in cell-fate determination, tissue patterning and
tumorigenesis. Wnt proteins signal through seven-pass transmembrane receptors of the frizzled …

The nephron is a highly specialised segmented structure that provides essential filtration
and resorption renal functions. It arises by formation of a polarised renal vesicle that …

Understanding the role of gene duplications in establishing vertebrate innovations is one of
the main challenges of Evo-Devo (evolution of development) studies. Data on evolutionary …

Activation of mitogen‐activated protein kinase (MAPK) in maturing mouse oocytes occurs
after synthesis of Mos, a MAPKKK. To investigate whether Mos acts only through MEK1, we …

Deciphering the fundamental mechanisms controlling cardiac specification is critical for our
understanding of how heart formation is initiated during embryonic development and for …

The mechanisms by which a subset of mesodermal cells are committed to a nephrogenic
fate are largely unknown. In this study, we have investigated the role of retinoic acid (RA) …

Vertebrate oocytes arrest in metaphase of the second meiotic division (MII), where they
maintain a high cdc2/cyclin B activity and a stable, bipolar spindle because of cytostatic factor (…