User profiles for Unnati Kapadnis
 | Unnati Kapadnisscientist Verified email at agios.com Cited by 347 |
[PDF][PDF] Itaconate confers tolerance to late NLRP3 inflammasome activation
Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR)
stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death …
stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death …
Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model
…, PA Kosinski, S Yu, U Kapadnis… - Blood Cells, Molecules …, 2022 - Elsevier
Polymerization of deoxygenated sickle hemoglobin (HbS) leads to erythrocyte sickling.
Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this reduces …
Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this reduces …
Volumetric absorptive microsampling as an effective microsampling technique for LC–MS/MS bioanalysis of biomarkers in drug discovery
U Kapadnis, C Locuson, H Okamura, GD Rienzo… - Bioanalysis, 2023 - Future Science
Aim: Develop and validate a volumetric absorptive microsampling (VAMS)-based LC–MS/MS
method to support the bioanalysis of amino acid and carboxylic acid biomarkers in mouse …
method to support the bioanalysis of amino acid and carboxylic acid biomarkers in mouse …
Identification and Validation of N-Acetylputrescine in Combination With Non-Canonical Clinical Features As a Parkinson's Disease Biomarker Panel
KW Peng, A Klotz, A Guven, U Kapadnis, S Ravipaty… - bioRxiv, 2021 - biorxiv.org
Parkinson’s disease is a progressive neurodegenerative disorder in which loss of dopaminergic
neurons in the substantia nigra results in a clinically heterogeneous group with variable …
neurons in the substantia nigra results in a clinically heterogeneous group with variable …
[PDF][PDF] Please let us know how this document benefits you.
M Bambouskova, L Potuckova, T Paulenda, M Kerndl… - digitalcommons.wustl.edu
Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR)
stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death …
stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death …
Microsampling: considerations for its use in pharmaceutical drug discovery and development
N Spooner, KD Anderson, J Siple, ER Wickremsinhe… - Bioanalysis, 2019 - Future Science
There is growing interest in the implementation of microsampling approaches for the quantitation
of circulating concentrations of analytes in biological samples derived from nonclinical …
of circulating concentrations of analytes in biological samples derived from nonclinical …