Background Selected groups of patients with bipolar and unipolar disorder have an increased
mortality rate from suicide and natural causes of death. However, there has been no …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

A study of mortality for all patients with a first hospital diagnosis of schizophrenia in Stockholm
County, Sweden, during 1973 to 1995 was performed, by linking the in-patient register …

Background Excess mortality among patients with severe mental disorders has not
previously been investigated in detail in large complete national populations. Objective To …

Objective Excess mortality from diseases and medical conditions (natural death) in persons
with psychiatric disorders has been extensively reported. Even in the Nordic countries with …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …

Although mortality in patients with schizophrenia is two to three times higher than that in the
general population, little is known about time trends in mortality rates. 1-3 We aimed to …

We aimed to estimate the value of structured interviews, medical records and Swedish
register diagnoses for assessing lifetime diagnosis of patients with schizophrenia. Psychiatric …

Even though schizophrenia has a strong hereditary component, departures from simple
genetic transmission are prominent. DNA methylation has emerged as an epigenetic …

Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …