We present a data-independent acquisition mass spectrometry method, ultradefinition (UD)
MS E . This approach utilizes ion mobility drift time-specific collision-energy profiles to …

Exosomes derived from solid tumor cells are involved in immune suppression, angiogenesis,
and metastasis, but the role of leukemia-derived exosomes has been less investigated. …

MaxDIA is a software platform for analyzing data-independent acquisition (DIA) proteomics
data within the MaxQuant software environment. Using spectral libraries, MaxDIA achieves …

Consistent and accurate quantification of proteins by mass spectrometry (MS)-based
proteomics depends on the performance of instruments, acquisition methods and data analysis …

Unbiased data-independent acquisition (DIA) strategies have gained increased popularity in
the field of quantitative proteomics. The integration of ion mobility separation (IMS) into DIA …

Nanoparticle applications in biotechnology and biomedicine are steadily increasing. In biological
fluids, proteins bind to nanoparticles that form the protein corona, crucially affecting the …

Efficient and reproducible sample preparation is a prerequisite for any robust and sensitive
quantitative bottom-up proteomics workflow. Here, we performed an independent …

The intestinal microbiota influences mammalian host physiology in health and disease
locally in the gut but also in organs devoid of direct contact with bacteria such as the liver and …

Located at neuronal terminals, the postsynaptic density (PSD) is a highly complex network
of cytoskeletal scaffolding and signaling proteins responsible for the transduction and …

We propose a structure-based protocol for the development of customized covalent inhibitors.
Starting from a known inhibitor, in the first and second steps appropriate substituents of the …