A large body of published work shows that proton (hydrogen 1 [ 1 H]) magnetic resonance (MR)
spectroscopy has evolved from a research tool into a clinical neuroimaging modality. …

Proton MRS ( 1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and
has been shown to aid the clinical management of several brain diseases. Although most …

Proton-Magnetic Resonance Spectroscopy (MRS) is a non-invasive brain imaging technique
used to measure the concentration of different neurochemicals. “Single-voxel” MRS data is …

Background Parkinson disease (PD) is characterized by the degeneration of nigrostriatal
dopaminergic neurons. However, postmortem evidence indicates that the pathology of lower …

Neuroplasticity is a fundamental property of the nervous system that is maximal early in life,
within the critical period [1–3]. Resting GABAergic inhibition is necessary to trigger ocular …

Several laboratories have consistently reported small concentration changes in lactate,
glutamate, aspartate, and glucose in the human cortex during prolonged stimuli. However, …

Key points The ability to learn new motor skills is supported by plasticity in the structural and
functional organisation of the primary motor cortex in the human brain. Changes inhibitory to …

Purpose To determine the test‐retest reproducibility of neurochemical concentrations obtained
with a highly optimized, short‐echo, single‐voxel proton MR spectroscopy (MRS) pulse …

Purpose To determine whether neurochemical concentrations obtained at two MRI sites
using clinical 3T scanners can be pooled when a highly optimized, nonvendor short‐echo, …

Mutations in the isocitrate dehydrogenase genes (IDH1/2) occur often in diffuse gliomas,
where they are associated with abnormal accumulation of the oncometabolite 2-…