The interplay between tumors and their immunologic microenvironment is complex and difficult
to decipher, but its understanding is of seminal importance for the development of novel …

Solid tumors, beyond mere accumulation of cancer cells, form a complex ecosystem consisting
of normal epithelial cells, fibroblasts, blood and lymphatic vessels, structural components, …

Objective To evaluate the safety of rituximab treatment before and during pregnancy in
women with MS and neuromyelitis optica spectrum disorders (NMOSDs) who may be at risk of …

Background The role of tumor-infiltrating immune cells in the early metastatic invasion of
colorectal cancer is unknown. Methods We studied pathological signs of early metastatic …

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

Appropriate localization and migration of T cells is a prerequisite for antitumor immune
surveillance. Studies using fixed tumor samples from human patients have shown that T cells …

Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced
by gene targeting in embryonic stem cells. Heterozygous females showed almost complete …

In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …