The therapy of complex neurodegenerative diseases requires the development of
multitarget‐directed drugs (MTDs). Novel indole derivatives with inhibitory activity towards acetyl/…

Acute kidney injury is a common complication of rhabdomyolysis. A better understanding of
this syndrome may be useful to identify novel therapeutic targets because there is no specific …

Microglia controls the immune system response in the brain. Specifically, the activation and
dysregulation of the NLRP3 inflammasome is responsible for the initiation of the …

Background and Purpose Activation of astrocytes contributes to synaptic remodelling, tissue
repair and neuronal survival following traumatic brain injury (TBI). The mechanisms by …

NLRP3 is involved in the pathophysiology of several inflammatory diseases. Therefore,
there is high current interest in the clinical development of new NLRP3 inflammasome small …

Background Inflammasomes are cytosolic multiprotein complexes which, upon assembly,
activate the maturation and secretion of the inflammatory cytokines IL‐1β and IL‐18. However, …

Background and Purpose Ischaemic stroke is a leading cause of death, disability, and a
high unmet medical need. Post‐reperfusion inflammation and an up‐regulation of toll‐like …

There is a lack of effective therapies for stroke patients; its treatment is even more difficult
considering the unexpected onset of the disease. In the last decade, melatonin has emerged …

Therapeutic interventions on pathological processes involved in the ischemic cascade, such
as oxidative stress, neuroinflammation, excitotoxicity and/or apoptosis, are of urgent need …

Despite the numerous research studies on traumatic brain injury (TBI), many physiopathologic
mechanisms remain unknown. TBI is a complex process, in which neuroinflammation and …