Lighter variations of pigmentation in humans are associated with diminished number, size,
and density of melanosomes, the pigmented organelles of melanocytes. Here we show that …

Human skin pigmentation shows a strong positive correlation with ultraviolet radiation intensity,
suggesting that variation in skin color is, at least partially, due to adaptation via natural …

… they are not integral melanosomal proteins, they have important functions, such as
melanophilin/Slac2-a, a binding protein involved in the transport of melanosomes via myosin Va. In …

Zebrafish, a model developmental genetic organism, is being increasingly used in behavioural
studies. We have initiated studies designed to evaluate the response of zebrafish to …

We have isolated and characterized cDNA clones encoding the human and rat Na,K-ATPase
β3 subunit isoform. The human cDNA encodes a polypeptide of 279 amino acids that …

10.7554/eLife.44898.001 Organismal phenotypes frequently involve multiple organ systems.
Histology is a powerful way to detect cellular and tissue phenotypes, but is largely …

A major challenge in personalized medicine is the lack of a standard way to define the
functional significance of the numerous nonsynonymous, single nucleotide coding variants that …

We have identified a cohort of zebrafish expressed sequence tags encoding eight Na,K-ATPase
α subunits and five β subunits. Sequence comparisons and phylogenetic analysis …

The A2A adenosine receptor (AdR) subtype has emerged as an attractive target in the pursuit
of improved therapy for Parkinson’s disease (PD). This report focuses on characterization …

We have examined the relationship between Na,K-ATPase and FGF-2 secretion in transfected
primate cells. FGF-2 lacks a classic hydrophobic export signal, and the mechanisms …