User profiles for V. K. Ulaganathan

Vijay K. Ulaganathan

Associate Professor of Biochemistry & Molecular Biology, @UL and Research Group @UMG
Verified email at med.uni-goettingen.de
Cited by 715

T cells become licensed in the lung to enter the central nervous system

F Odoardi, C Sie, K Streyl, VK Ulaganathan… - Nature, 2012 - nature.com
The blood–brain barrier (BBB) and the environment of the central nervous system (CNS)
guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple …

Germline variant FGFR4 p. G388R exposes a membrane-proximal STAT3 binding site

VK Ulaganathan, B Sperl, UR Rapp, A Ullrich - Nature, 2015 - nature.com
… Vijay Ulaganathan and colleagues now show that this polymorphic variant, termed
rs351855-G/A, creates a binding site in the FGFR4 protein for the transcription factor STAT3. This in …

Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system

…, F Lühder, E Breunig, D Schild, VK Ulaganathan… - Brain, 2010 - academic.oup.com
Nicotinic acid adenine dinucleotide phosphate represents a newly identified second messenger
in T cells involved in antigen receptor-mediated calcium signalling. Its function in vivo is, …

[HTML][HTML] STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion

…, C Yanucil, C Faul, VK Ulaganathan - The Journal of …, 2018 - Am Soc Clin Investig
Immune evasion and the suppression of antitumor responses during cancer progression
are considered hallmarks of cancer and are typically attributed to tumor-derived factors. …

Neo-epitope tissue transglutaminase autoantibodies as a biomarker of the gluten sensitive skin disease—Dermatitis herpetiformis

…, A Szaflarska-Poplawska, VK Ulaganathan… - Clinica Chimica …, 2013 - Elsevier
BACKGROUND: The deamidated gliadin peptides (DGP) cross linked to human tissue
transglutaminase (tTg) comprises a novel neo-epitope structure (Neo-tTg) for serological …

[HTML][HTML] Sequential salinomycin treatment results in resistance formation through clonal selection of epithelial-like tumor cells

F Kopp, A Hermawan, PS Oak, VK Ulaganathan… - Translational …, 2014 - Elsevier
Acquiring therapy resistance is one of the major obstacles in the treatment of patients with
cancer. The discovery of the cancer stem cell (CSC)–specific drug salinomycin raised hope for …

A strategy for uncovering germline variants altering anti-tumor CD8 T cell response

VK Ulaganathan, MH Vasileva - Journal of Genetics and Genomics, 2023 - Elsevier
… anesthesia, immunization, and euthanasia by cervical dislocation, were carried out by
trained and licensed personnel (File numbers: 33.9-42502-14-Mole and T20/8-Ulaganathan) in …

Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants

VK Ulaganathan, A Ullrich - Molecular & Cellular Oncology, 2016 - Taylor & Francis
In cancer biology, somatic mutations in the extracellular (ligand binding) and cytosolic (functional/catalytic)
domains are pursued with great interest. However, in our recent publication …

Membrane Anchorage‐Induced (MAGIC) Knockdown of Non‐synonymous Point Mutations

VK Ulaganathan - ChemBioChem, 2022 - Wiley Online Library
The promise of personalized medicine for monogenic and complex polygenic diseases
depends on the availability of strategies for targeted inhibition of disease‐associated …

[HTML][HTML] TraPS-VarI: Identifying genetic variants altering phosphotyrosine based signalling motifs

VK Ulaganathan - Scientific Reports, 2020 - nature.com
Patient stratification and individualized therapeutic strategies rely on the established
knowledge of genotype-specific molecular and cellular alterations of biological and therapeutic …