Tumor cells secrete not only a variety of soluble factors, but also extracellular vesicles that
are known to support the establishment of a favorable tumor niche by influencing the …

Aim Interest in human saliva proteomics for disease‐specific biomarker screening increased
in the last decade. We used whole saliva samples from periodontally healthy and diseased …

BACKGROUND: Saliva collection devices are widely used for large-scale screening
approaches. This study was designed to compare the suitability of three different whole-saliva …

Wnt signaling plays a central role in development, adult tissue homeostasis, and cancer.
Several steps in the canonical Wnt/β-catenin signaling cascade are regulated by ubiquitylation, …

Ischemia-reperfusion injury (IRI) is the leading cause of ARF. A pathophysiologic role of the
coagulation system in renal IRI has been established, but the functional relevance of …

Gliomas are the most common of the primary intracranial tumors with astrocytomas constituting
about 40%. Using clinically and histologically assessed astrocytomas, we have studied …

Growth factor receptor mediated signaling is meanwhile recognized as a complex signaling
network, which is initiated by recruiting specific patterns of adaptor proteins to the …

Background and Objective Interest in human saliva is increasing for disease‐specific biomarker
discovery studies. However, protein composition of whole saliva can grossly vary with …

Stressosomes are stress-sensing protein complexes widely conserved among bacteria.
Although a role in the regulation of the general stress response is well documented in Gram-…

Macrophages are essential components of the innate immune system and crucial for
pathogen elimination in early stages of infection. We previously observed that bone marrow-…