The maintenance of chromosome termini, or telomeres, requires the action of the enzyme
telomerase, as conventional DNA poly-merases cannot fully replicate the ends of linear …

Telomeres protect the ends of linear chromosomes from degradation and abnormal
recombination events, and in vertebrates may be important in cellular senescence and cancer. …

… We have found no evidence that p23 and Hsp90 are required to allow physical association
of hTERT with hTR, but they may be required to allow functional association (VM Tesmer, …

Most normal diploid human cells do not express telomerase activity and are unable to
maintain telomere length with ongoing cell divisions. We show that the length of the single-…

G protein–coupled receptor kinase 2 (GRK2) plays a key role in the desensitization of G
protein–coupled receptor signaling by phosphorylating activated heptahelical receptors and by …

The human telomerase RNA component (hTR) is present in normal somatic cells at lower
levels than in cancer-derived cell lines. To understand the mechanisms regulating hTR levels …

Telomeres in yeast are late replicating. Genes placed next to telomeres in yeast can be
repressed (telomere positional effects), leading to the hypothesis that telomeres may be …

We have mapped the 5′ and 3′ boundaries of the region of the human telomerase RNA (hTR)
that is required to produce activity with the human protein catalytic subunit (hTERT) by …

We describe the 2.6-Å crystal structure of human G protein-coupled receptor kinase (GRK)-6,
a key regulator of dopaminergic signaling and lymphocyte chemotaxis. GRK6 is a …

The enzyme phospholipase C-β (PLCβ) is a crucial regulator of intracellular calcium levels
whose activity is controlled by heptahelical receptors that couple to members of the G q family …